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Madan, Jyotsna
- Bone Marrow Aspiration and Bone Marrow Biopsy in Hematological Malignancies - A 10 Year Clinicopathological Study
Authors
1 Department of Pathology, Mayo Institute of Medical Sciences, Gadia, Barabanki, Lucknow, Uttar Pradesh, IN
2 Department of Medicine, School of Medical Science and Research, Sharda Hospital, Greater Noida, Uttar Pradesh, IN
3 Department of Pathology, School of Medical Science and Research, Sharda Hospital, Greater Noida, Uttar Pradesh, IN
4 Department of Pathology, Santosh Medical College, Ghaziabad, Uttar Pradesh, IN
Source
International Journal of Contemporary Medicine, Vol 1, No 1 (2013), Pagination: 95-99Abstract
Introduction: Hematological malignancies may derive from either of the two major blood cell lineages- Myeloid and lymphoid cell lines. Lymphoma, lymphocytic leukemias and myeloma are from the lymphoid line, while acute and chronic myelogenous leukemia, myelodysplastic syndromes and myeloproliferative diseases are myeloid in origin.
Objectives : The present study (2002 - 2012) has been aimed to report our bone marrow aspiration and biopsy examination experience with one hundred seven (107) patients of hematological malignancies from North India. and compare the results of bone marrow aspirations with bone marrow biopsy.
Material and Methods: In our study we have included cases of hematological malignancies (Leukemia, Malignant Lymphoma and Multiple Myeloma). In each case serial bone marrow aspiration and biopsy were done before and after chemotherapy and radiotherapy. Aspirate particles, smears, touch imprints of the biopsy core and paraffin sections of the biopsy core were routinely examined.
Results: Out of these one hundred seven (107) cases of hematological malignancies, non-Hodgkin's lymphoma (NHL) were maximum thirty cases (28.03%), followed by chronic myeloid leukemia (CML) twenty cases (18.69%), acute lymphoblastic leukemia (ALL) fifteen cases (14.01%), acute myeloid leukemia (AML) twelve cases (11.21%), multiple myeloma (MM) eleven cases (10.28%), chronic lymphocytic leukemia (CLL) ten cases (09.34%), Hodgkin's lymphoma (HL) eight cases (07.47%) and hairy cell leukemia (HCL) one case (0.93%).
Conclusion: Hematological malignancies were more prevalent in males and more common in first and third decades of life followed by fifth decade In this study bone marrow aspiration was found adequate in hematological malignancies especially in leukemia. Trephine biopsy is essential for diagnosis, when a dry tap or bloody tap occurs as a result of fibrotic or very densely cellular bone marrow. There is virtually no contraindication to aspiration and needle biopsy of the bone marrow. In malignant lymphomas, which are infiltrating to bone marrow, bone marrow biopsy (BMB) was found superior to bone marrow aspiration (BMA) as well as bone marrow involvement is a less favorable prognostic sign than the patients without bone marrow involvement.
Keywords
Bone Marrow, Hematological Malignancies.References
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- Role of Bone Marrow Study in Malignant Disorders: A Clinicopathological Study of 185 Patients
Authors
1 Department of Pathology, Mayo institute of medical sciences, Gadia, Barabanki, Lucknow, Uttar Pradesh, IN
2 Department of Medicine, School of Medical Science and Research, Greater Noida, Uttar Pradesh, IN
3 Department of Pathology, Dr. B. R. Sur Homeopathic Medical College and Hospital and Research center, New Delhi, IN
4 Department of Pathology, School of Medical Science and Research, Greater Noida, Uttar Pradesh, IN
5 Santosh Medical College, Ghaziabad, Uttar Pradesh, IN
Source
International Journal of Contemporary Medicine, Vol 1, No 2 (2013), Pagination: 36-40Abstract
Introduction: Bone marrow is a reservoir of stem cells and is the site of origin of numerous primary hematological malignancies and is commonly infiltrated by malignant cells in non-hematological malignancies in advanced stages. Objectives: The present study (2002 - 2012) has been aimed to report our experience with one hundred eighty five (185) patients from North India. A comparative study of bone marrow aspiration (BMA) and bone marrow biopsy (BMB) was done simultaneously, where the clinical history was correlated before and after chemotherapy and radiotherapy. Material and Method: In our study we have included cases of malignant disorders (hematological malignancies and non-hematological malignancies). In each case bone marrow aspiration and biopsy were done before and after chemotherapy and radiotherapy. Aspirate particles, smears, touch imprints of the biopsy core and paraffin sections of the biopsy core were routinely examined. Results: In our study we have included cases of hematological malignancies (Leukemia, Multiple Myeloma and Malignant Lymphoma) and non-hematological malignancies (Carcinoma of Breast, Prostate, Lung, Kidney, Urinary bladder, GIT, Thyroid, Round cell tumors and Indeterminate tumors). In hematological malignancies, non-Hodgkin's lymphomas (NHL) were maximum thirty cases (28.03%) and hairy cell leukemia (HCL) one case (0.93%). In non-hematological malignancies or primary tumors, there were maximum cases of breast carcinoma, twenty four cases (30.76%) and minimum two cases of thyroid carcinoma (02.56%). Conclusion: Malignant disorders were more prevalent in males and were seen in all the age groups. In this study bone marrow aspiration was found adequate in hematological malignancies especially in leukemia. Bone marrow biopsy found to be more informative in lymphoma and Metastatic tumors Bone marrow involvement indicated poor prognosis in metastatic tumors except in seven cases (18.42%) of malignant lymphoma. There was no complication of the procedure even in cases of thrombocytopenia.Keywords
Bone Marrow, Hematological Malignancies, Non-Hematological MalignanciesReferences
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- Richard A. Savage, George C. Hoffman and Keren Shaker R.N. (1978): Diagnostic problems involved in detection of metastatic neoplasm of bone marrow aspirates compared with needle biopsy. American J. Clin. Pathol. (70): 623 – 627.
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- Stephen E. Jones, Saul A. Rosenberg and Henry S. Kaplan (1972): Non-Hodgkin’s lymphoma. 1- Bone marrow involvement. Cancer. (5): 954 - 960.
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- Retrospective and Prospective Study of Germ Cell Tumors of the Ovary in Young and Adolescent Girls
Authors
1 Department of Pathology, Santosh Medical College, Ghaziabad.
Source
Indian Journal of Public Health Research & Development, Vol 4, No 2 (2013), Pagination: 169-172Abstract
Background and Objectives: Objective in this retrospective and prospective study was to find out the incidence of various germ cell tumors of the ovary up to 20 years of the age in the last 10 years, and to correlate clinical and pathological findings for better outcome.
Materials and Methods: Forty Two cases of ovarian germ cell tumors were studied from 2000 to 2010.Clinical data and histopathological findings were recorded.
Result: On analysis of these forty two cases, mature teratoma (57%) was the most common benign tumor and dysgerminoma (31%) was the commonest malignant tumor. Majority of the tumors were in the age group of 10-20 years.
Conclusion: Ovarian germ cell tumors are uncommon but in children and adolescent, more than 60% of ovarian neoplasms are of germ cell origin and one third are malignant. Clinical stage of the neoplasm is one of the important prognostic factors. So, early diagnosis is necessary for the better and timely management in terms of preservation of reproductive life and 5 years survival rate in cases of malignant tumors.
Keywords
Germ Cell Tumors, Ovary, Young and Adolescent GirlsReferences
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